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Therapeutic efficacy of Clompanus pubescens leaves fractions via downregulation of neuronal cholinesterases/Na+-K+ATPase/IL-1 β, and improving the neurocognitive and antioxidants status of streptozotocin-induced diabetic rats

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By A. S. Onikanni, Simona Cavalu, G. El-Saber Batiha et al.

Clompanus pubescens leaf fractions displayed
hypoglycemic effect in streptozotocininduced
diabetic rats (A) Fasting blood
glucose level (FBGL) and (B) body weight of
streptozotocin-induced diabetic rats. Copyright A. S. Onikanni, Simona Cavalu, G. El-Saber Batiha et al.
Clompanus pubescens leaf fractions improved the neuronal antioxidant status of streptozotocin-induced diabetic rats. Effect of C. pubescens leaf fractions on the
level of (A) GSH and activities of (B) SOD (C) CAT, (D) GST, and (E) GPx in the brain of streptozotocin-induced diabetic rats. Copyright A. S. Onikanni, Simona Cavalu, G. El-Saber Batiha et al.
The level of Interleukin-1 β (IL-1 β) in streptozotocin-induced diabetic
rats after administration of Clompanus pubescens leaf fractions.Copyright A. S. Onikanni, Simona Cavalu, G. El-Saber Batiha et al.
Clompanus pubescens leaf fractions ameliorates
cognitive deficits in streptozotocin-induced diabetic rats.
Effect of C. pubescens leaf fractions on (A) Y-Maze test, and
(B) novel object recognition (NOR) test.Copyright A. S. Onikanni, Simona Cavalu, G. El-Saber Batiha et al.
3D and 2D views of the receptor-ligand interactions between butyrylcholinesterase (BChE) and the identified
compounds from ethyl acetate fraction of Clompanus pubescens. Copyright A. S. Onikanni, Simona Cavalu, G. El-Saber Batiha et al.
3D and 2D views of the receptor-ligand interactions between acetylcholinesterase (AChE) and the identified compounds
from ethyl acetate fraction of Clompanus pubescens. Copyright A. S. Onikanni,
Simona Cavalu, G. El-Saber Batiha et al.
2D view of the receptor-ligand interactions between sodium-potassium adenosine triphosphatase (Na+-K+-ATPase) and the identified
compounds from ethyl acetate fraction of Clompanus pubescens. Copyright A. S. Onikanni,
Simona Cavalu, G. El-Saber Batiha et al.
In silico gastrointestinal absorption and Blood Brain Barrier Penetration
modelling of the identified compounds from the ethyl acetate fraction of
Clompanus pubescens. Copyright A. S. Onikanni,
Simona Cavalu, G. El-Saber Batiha et al.

Herein, we evaluated the neuroprotective and antioxidant properties of different fractions (ethyl acetate, N-butanol and residual aqueous) of Clompanus pubescens leaves in streptozotocin (STZ)-induced diabetic rats. Our results revealed a significant elevation in the levels of blood glucose, pro-inflammatory cytokines, lipid peroxidation, neuronal activities of acetylcholinesterase, butyrylcholinesterase, nitric oxide, epinephrine, norepinephrine, and Na+/K+-ATPase in diabetic non treated rats. In addition, decreased levels of enzymatic and non-enzymatic antioxidants were observed. Treatment with different fractions of C. pubescens leaves resulted in significant reversal of the biochemical alteration
and improved the neurocognitive deficit in STZ induced diabetic rats. Copyright A. S. Onikanni, Simona Cavalu, G. El-Saber Batiha et al.

Full text at https://www.sciencedirect.com/science/article/pii/S0753332222001184?via%3Dihub