Prof. Dr. SIMONA CAVALU

University of Oradea, Faculty of Medicine and Pharmacy

Department of Preclinical Sciences, P-ta 1 Decembrie 10, Oradea 410081, Romania

Phone: (004) 0259/408.105; (004) 0259/476.724

Email: scavalu@rdslink.ro; scavalu@uoradea.ro

EDUCATION

Babes-Bolyai University Cluj-Napoca, Romania, Faculty of Physics, Sept.1983- June1987.

PhD: Physics/Biophysics. Magna cum Laude, Babes-Bolyai University Cluj-Napoca, 2001.

Disertation: EPR and Raman Spectroscopy on some hemic and non-hemic proteins. Supervisor: Prof. dr. Simon Simon.

GRANTS AND FELLOWSHIPS

• TEMPUS Fellowship, Medical Biophysics, University of Rouen-Charles Nicole Hospital, Rouen, France, Jan. – Apr. 1996.
• Post-universitary course: Modern Spectroscopic Techniques in Medical Biophysics, organized by Institute for Biodiagnostic Otawa, Canada, June 1998.
• Post-doctoral short stage: New Techniques in Spectroscopy of Biological Molecules, Bobigny, University Paris XIII, Sept. 2007.
• Cours de Formation post-universitaire dans le domaine des sciences de la vie, Universite Francophone CEFOR, Sept. 2002.
• Research stage at ISM-CNR Rome, October 2018, Novenber 2019.

TEACHING EXPERIENCE

• Professor – University of Oradea, Faculty of Medicine and Pharmacy. Medical Biophysics, 2008-present.
• Assoc. Professor – University of Oradea, Faculty of Medicine and Pharmacy. Medical Biophysics, 2005-2008.
• Lecturer – University of Oradea, Faculty of Medicine and Pharmacy. Medical Biophysics, 2000-2005.
• Teaching Assistant – I. Hatieganu University of Medicine and Pharmacy Cluj-Napoca. Medical Biophysics, 1990-2000.

VISITING PROFESSOR

• Delta University Egypt, 2021-2023
• Istanbul Technical University – Sept. 2010, Nov. 2011, February- May 2013.
• Bezmialem Vakif University of Medicine, July 2015
• University of Debrecen, Hungary – april 2010.
• Meerut College, Department of Physics, India – February 2006.

RESEARCH EXPERIENCE

• Contributions in the field of biomacromolecules structure using high sensitive methods and techniques
• Conformational changes of proteins and nanostructures studied by vibrational spectroscopy (FTIR, FT Raman, Surface Enhanced Raman Spectroscopy) and EPR spectroscopy combined with spin labeled techniques.
• Contributions in the field of nanostructured biomaterials production and applications.
• Structural investigations of biocomposites for radiotherapy and hyperthermia by DTA, Scanning Electron Microscopy, Nuclear Magnetic Resonance, Electron Paramagnetic Resonance, XRD, XPS, FTIR and FT Raman spectroscopy.
• Bioactivity and biocompatibility investigations on bone cements and bioceramics for dental and orthopedic applications, in vitro and in vivo tests – animal model.
• Anticancer treatments- novel therapeutic approach.
• Drug delivery, nanocomposites
• Experience in National Research Projects (CNCSIS-UEFISCDI, ANCS) and International Projects as Project Manager.
• 1 Patent
  
• AWARDS:   2018 Gold Medal – National Research Council of Thailand (NRCT),

2018 Special Honour of Invention – Toronto International Society of Innovation & Advanced Skills (TISIAS),

2018 Special Award & Gold Medal – Malaysian Research & Innovation Society, 

2018 Special Award & Medal – Association of Polish Inventors and Rationalizers

2014 „Daniel Bunea” Award of Romanian Society of Biomaterials for the most relevant contribution in the field of biomaterials research

2014 EXCELENCE AWARD -Romanian Society of Biomaterials

Habilitation Thesis (2015) Title: New developments on functional biomaterials with tunable properties for orthopedic, dental and drug delivery applications

INVITED TALKS/CHAIRMAN AT INTERNATIONAL CONFERENCES

• ICOPVS 2006, Meerut, India.
• Perspectives in Esthetic Adhesive Dentistry, 2010 Szeged, Hungary.
• 8th International Conference on Physics of Advanced Materials, 2008, Iasi, Romania.
• Bioceramics 23, Istanbul 2011.
• 13th Ceramics, Cells and Tissues 2011, Faenza – Italy.
• 5th BIOMMEDD 2012, Constanta, Romania.
• Bioceramics 24, Fukuoka, Japan, 2012.
• Bioceramics 25, Bucharest, Romania, 2013
• APMAS 2014, Fethiye-Mugla, Turkey.
• ICCE 2014 Malta
• BIOREMED 2015, Felix Bath Romania
• EMN Meeting on Biomaterials, Phuket, Thailand 2016
• BIOREMED 2017, Timisoara, Romania
• IMTMC 2017, Istanbul, Turkey
• BIOMAH 2019 Rome, Italy
• MTM 2023 Istanbul, Turkey

PROFESSIONAL ASSOCIATIONS

• Romanian Society of Biomaterials (affiliated to ESB)
• Romanian Society of Pure and Applied Biophysics (affiliated to EBSA)
• American Association for Advancement of Science.
• International Society for Ceramics in Medicine

SELECTED PUBLICATIONS    

• Sameh Saber, Alexandru Madalin Hasan, Osama A. Mohammed, [….]  Simona Cavalu.  Ganetespib (STA-9090) augments sorafenib efficacy via necroptosis induction in hepatocellular carcinoma: Implications from preclinical data for a novel therapeutic approach.Biomedicine & Pharmacotherapy 164 (2023). doi.org/10.1016/j.biopha.2023.114918
• Mona H. Zohny, Simona Cavalu, Mahmoud Youssef, Sameh Saber et al. Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: A novel approach for filling an unmet medical need. 2022; Biomedicine & pharmacotherapy 148(1):112723
  DOI: 10.1016/j.biopha.2022.112723
• S. Cavalu, Hossam Sharaf, Sameh Saber et al. EAmbroxol, a mucolytic agent, boosts HO-1, suppressesNF-κB, and decreases the susceptibility of the inflamed ratcolon to apoptosis: A new treatment option for treatingulcerative colitis.The FASEB Journal.2022;36:e22496. https://doi.org/10.1096/fj.202200749R
• Cavalu, S.; Elbaramawi,S.S.; Eissa, A.G.; Radwan, M.F.; S.Ibrahim, T.; Khafagy, E.-S.; Lopes,B.S.; Ali, M.A.M.; Hegazy, W.A.H.;Elfaky, M.A. Characterization of theAnti-Biofilm and Anti-QuorumSensing Activities of theβ-Adrenoreceptor AntagonistAtenolol against Gram-NegativeBacterial Pathogens. Int. J. Mol. Sci.2022, 23, 13088.
• Dănilă, C.; Cardos, I.A.;Pop-Crisan, A.; Marc, F.; Hoza, A.;Chirla, R.; Pascalău, A.; Magheru, C.;Cavalu, S. Correlations betweenEndoscopic and HistopathologicalAssessment of Helicobacterpylori-Induced Gastric Pathology—ACross-Sectional Retrospective Study.Life 2022, 12, 2096
• S. Cavalu, J. Prokisch, V. Laslo, S. Vicas, Preparation, structural characterisation and release strudy of novel hybrid microspheres entrapping nanoselenium, produced by green synthesis, IET Nanobiotechnology 2016, doi: 10.1049/iet-nbt.2016.0107, www.ietdl.org.
• S. Cavalu, I. Bratu, A. Popa, Gh. Borodi, A. Maghiar, New evidences of key factors involved in ‘Silent Stones” etiopathogenesis and trace elements, Biological Trace Elements Research (2015) DOI: 10.1007/s12011-015-0361-0
•  I. Antoniac, Simona Cavalu, T. Traistaru (Eds.) Bioceramics, vol.25, Trans Tech Publications Zurich, ISBN 13 978-3-03785-899-8, 420 pg., 2013.
•  O. Ormanci, I. Akin, F. Sahin, O. Yucel, V. Simon, Simona Cavalu, G. Goller, Spark Plasma sintered A2O3-YSZ-TiO2 composites: Processing, characterization and in vivo evaluation, Materials Science and Engineering C, 40 (2014) 16-23. IF=2.64.
• Simona Cavalu, C. Ratiu, O. Ponta, V. Simon, D. Rugina, V. Miclaus, I. Akin, G. Goller, Improving osseointegration of alumina/zirconia ceramic implants by fluoride surface treatment, Digest Journal of Nanomaterials and Biostructures Vol. 9, No. 2 (2014) 797 – 808. IF=1.09.
• Simona Cavalu, V. Simon, F. Banica, I. Akin, G. Goller, Surface modification of alumina/zirconia bioceramics upon different fluoride-based treatments, Int. J. Appl. Ceram. Technol.,1-9(2013) DOI:10.1111/ijac.12075. IF=1.38.
•  Simona Cavalu, V. Simon, F. Banica, C. Gruian, E. Vanea, Spectroscopic and microscopic investigation of bioactive glasses for antibiotic controled released, Journal of Molecular Structure,1040 (2013) 47–52. IF=1.63.
• E. Vanea, C. Moraru, A. Vulpoi, Simona Cavalu, V. Simon, Freeze-dried and spray-dried zinc-containing silica microparticles entrapping insulin, J Biomater Appl published online 28 August 2013, DOI: 10.1177/0885328213501216. IF=2.64
• S. Cavalu, V. Simon, F. Banica, In vitro study of collagen coating by elecrodeposition on acrylic bone cement with antimicrobial potential, Digest J. Nanomaterials and Biostructures,vol.6,nr.1 January-March, 87-97, 2011.
• S. Cavalu, V. Simon, G. Goller, I. Akin, Bioactivity and antimicrobial properties of PMMA/Ag2O acrylic bone cements collagen coated, Digest J. Nanomaterials and Biostructures,vol.6, nr.2 April-June, 779-790, 2011.
• Simon V., Cavalu S., Mocuta H., Vanea E., Prinz M., Neumann M., Surface functionalization of sol-gel derived aluminosilicates in simulated body fluids, Solid State Ionics, vol.180, issues 9-10,764-769, 2009.
• Cavalu S., Damian G., Rotational correlation times of 3-carbamoyl-2,2,5,5-tetramethyl-3pyrrolin-1-yloxy spin label with respect to heme and nonheme proteins, Biomacromolecules, vol 4,No.6,1630-1635, 2003.
• Cavalu S., Damian G., Dansoreanu M., EPR study of non-covalent spin labeled serumalbumin and hemoglobin, Biophysical Chemistry, vol.92, issue 2, pp.181-188, 2002.
• Cavalu S., Canta Panzaru S., Leopold N., Kiefer W., Raman and surface enhanced Raman spectroscopy of labeled proteins: serum albumin and cytochrome c, Biopolymers, vol.62, issue 6, pp.341-348, 2001.
• Canta Panzaru S., Cavalu S., Leopold N., Petry R., Kiefer W., Raman and surface enhanced Raman spectroscopy of tempyo spin labeled ovalbumin, J. Mol. Structure, vol. 565-566, pp. 225-229, 2001.