Amniotic membrane for ophthalmologic surgery

By Simona Cavalu et al.

Nano-Scale Modifications of Amniotic Membrane Induced by UV and Antibiotic Treatment: Histological, AFM and FTIR Spectroscopy Evidence

The efficiency of amniotic membrane (AM) transplantation in different types of ocular surface disorders is due to its outstanding properties such as antifibrotic, antibacterial, anti-inflammatory and antiangiogenic, working as a versatile scaffold to promote corneal tissue epithelialization.

Recurrent pterygium excision. Copyright Simona Cavalu et al.
Amniotic membrane used in ophthalmologic surgery to cover the remaining tissue defect due to the grade 3 recurrent pterygium excision: (a) grade 3 recurrent pterygium, preoperative appearance; (b) intraoperative aspects (the same patient); (c) intraoperative preparation of the amniotic membrane fragment to be applied on the remaining defect following recurrent pterygium excision; (d) intraoperative appearance—application of the AM fragment on the remaining defect and 10.0 thread suturing to the bulbar conjunctiva of the fragment; (e) the aspect of the patient’s cornea four weeks after surgery . Copyright Simona Cavalu et al.
 Histological and immunohistochemical examination of amniotic membrane. Copyright Simona Cavalu et al.
 Histological and immunohistochemical examination: (a,b) natural amniotic membrane (AMN); (c,d) amniotic membrane exposed to UV for 1 h (AUV); (e,f) amniotic membrane treated with gentamicin (40 mg/mL) (AG40); (g,h) amniotic membrane treated with gentamicin 80 mg/mL (AG0); (i,j) amniotic membrane treated with gentamicin 40 mg/mL and exposed to UV for 1 h (AGUV). Left panel: H&E staining; right panel: immunohistochemistry staining of collagen IV (antibody clone CIV 22). Scale: 100 μm. Copyright Simona Cavalu et al.

The full text of the paper is available at:

https://www.mdpi.com/1996-1944/14/4/863/htm

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